Indications for Nexium include l gastroesophageal reflux disease (GERD), both symptomatic noncorrosive and erosive GERD, as well as maintenance prevention of GERD, treatment of H. pylori infection combination with antibiotics, treatment of gastric and duodenal ulcers and treatment hypersecretory conditions.
Common Nexium Side Effects: Nexium, like the other PPI’s, has very few common set side effects. These include headache, diarrhea, nausea and abdominal pain.
Serious Nexium Side Effects: although not common Nexium side effects can be serious. Severe skin reactions including Stevens-Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis have been noted. Serious renal effects including interstitial must nephritis as well as serious allergic reactions including anaphylaxis have been noted. Blood disgraces, liver impairment, pancreatitis, and with long-term use both hypomagnesemia and atrophic gastritis have been noted. Esophageal disorders that are known to occur with gastroesophageal reflux disease but could possibly be related to Nexium include esophageal stricture, esophageal varices, Barrett’s esophagus and esophageal ulceration. The prolonged lack of stomach acid can lead to poor calcium absorption and increased risk of fractures is been noted as a serious Nexium side effects.
Contraindications, cautions and drug interactions: Nexium is contraindicated for use with several HIV drugs. Nexium should be avoided for use with numerous medications including several of the cephalosporin antibiotics, diazepam, clopidogrel, the azole antifungal medications, St. John’s wort, rifampin, and naproxen. Interestingly despite the manufacturers recommendation against the use of Nexium with naproxen a combination drug that includes Nexium and naproxen has been brought to market named Vimovo. Modification of treatment may be needed with warfarin, digoxin, citalopram, sucralfate, and peppermint oil. Caution is advised for use with fluvastatin, fluconazole, crizotinib, and the penicillins.
Pregnancy and Lactation: Nexium is considered pregnancy category B although it safety in lactation is unknown.
Nexium Pharmacology: Nexium is exclusively metabolized in the liver primarily through the CYP 450. It utilizes primarily the 2C19 system and is a 3A4 substrate.
- Gain Nexium Weight
Q: Can Simvastatin (Zocor), Estradiol or Nexium cause weight gain? A: Changes in weight and appetite are common side effects of hormones, like estradiol.
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